Tissue repair and regeneration depends on effective biological communication via autocrine and paracrine signaling. Plurisomes are secretory vesicles released by pluripotent stem cells, the active messengers of pluripotency. Pluripotent stem cells release reparative secretome in response to tissue or medium conditions.
Plurisomes are cultured in a clean laboratory setting, an ideal in-vitro medium that is devoid of the inflammatory and toxic millieu present in vivo. Given this nourishing environment, the Plurisomes contain highly specific messaging content coding for multi-tissue renewal and repair, including growth factors, peptides, messenger and micro RNA.
Pluripotency implies whole body reach. Pluripotent stem cells and their secreted exosomes are capable of repair and restoration of all 220+ tissue types in the human body. Their reach is comprehensive. Upon application, the therapeutic message of Plurisomes travels to all tissues of the body, signaling restoration and rejuvenation at any juncture of tissue biology.
The characterization of Plurisomes has revealed growth factors signaling metabolic rejuvenation, immunoregulation, tumor suppression and reversion, apoptosis, cell repair and growth. Clinical evidence indicates that Plurisome biodistribution is multi-tissue comprehensive.
A thorough review of embryonic and pluripotent stem cell scientific research and clinical application supports the expected potency and safety profile of Plurisomes and of Pluripotent Stem Cells. The advancement of Pluripotency for therapeutic use is ushering a new era in biologics medicine.
Plurisomes act in concert with physiology and immune system to create an anti-tumorigenic, highly regenerative environment. Safety concerns have been attenuated. Plurisomes are grown in-laboratory, in-vitro, without further embryonic harvesting. Ethical concerns are pacified. The crucial place of Pluripotency in regenerative medicine is restored.
